| CAS NO: | 1253901-26-6 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1253901-26-6 |
| Canonical SMILES | CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1 |
| 分子式 | C17H17NOS |
| 分子量 | 283.39 |
| 溶解度 | DMSO: 100 mM,Ethanol: 100 mM |
| 储存条件 | Store at 4℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active. Cook et al (2015) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 172 185 PMID:25220431 |Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID:21239511 |Leach et al (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 26 574 PMID:27002221 |
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