GPNA hydrochloride

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GPNA hydrochloride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

67953-08-6

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

GPNA hydrochloride 是一种 γ-谷氨酰转移酶 (GGT) 的知名底物。GPNA hydrochloride 是一种特定的谷氨酰胺 (Gln) 转运蛋白 ASCT2 抑制剂。GPNA hydrochloride 还抑制依赖 Na+ 的载体，如 SNAT 家族 (SNAT1/2/4/5) 和不依赖 Na+ 的亮氨酸转运蛋白 LAT1/2。GPNA 可逆地诱导 A549 细胞凋亡 (apoptosis)。

Cas No.	67953-08-6
别名	Γ-(P-硝基苯胺)-L-谷氨酸盐酸盐
Canonical SMILES	OC([C@@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl
分子式	C₁₁H₁₄ClN₃O₅
分子量	303.7
溶解度	DMSO: 125 mg/mL (411.59 mM)
储存条件	Store at 2-8°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. [1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.