ENPP1 Inhibitor C

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ENPP1 Inhibitor C

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2378640-92-5

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议

产品介绍

ENPP1 Inhibitor C (Compound C) 是一种有效的 ENPP1（外核苷酸焦磷酸酶/磷酸二酯酶 1）抑制剂，IC50 值为 0.26、0.48 和 2.0 μM 分别通过 TG-mAMP、pNP-TMP 和 ATP 测定法评估。 TG (Tokyo Green)-mAMP:一种新合成的灵敏 ENPP1 荧光探针。

Cas No.	2378640-92-5
Canonical SMILES	NC1=CC=CC(CC2=C(N(C)C)N3C(N=C2C)=NC=N3)=C1
分子式	C₁₅H₁₈N₆
分子量	282.3
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM. \|1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant breast cancer. J. Med. Chem. 62(20), 9254-9269 (2019).