| CAS NO: | 157182-48-4 |
| 包装 | 价格(元) |
| 10mg (solution) | 电议 |
| 25mg (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 361.6 |
| Cas No. | 157182-48-4 |
| Formula | C23H39NO2 |
| Synonyms | (S)-(+)-Arachidonyl-2'-Hydroxy-1'-Propylamide |
| Solubility | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| Chemical Name | N-(2S-hydroxypropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(C)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
S-2 methanandamide is a CB1 receptor ligand.
The cannabinoid receptor type 1 (CB1), is a G protein-coupled cannabinoid receptor located mainly in the central and peripheral nervous system. CB1 is also expressed in several cells relating to metabolism, such as muscle cells, fat cells, liver cells, and the digestive tract. The CB1 receptor has been involved in the maintenance of homeostasis in health and disease, preventing the development of excessive neuronal activity, reducing pain and other inflammatory symptoms. Enhanced receptor expression has been identified in human hepatocellular carcinoma tumor samples and human prostate cancer cells [2].
S-2 methanandamide was the second most potent CB1 receptor agonist in the methanandamide series. S-2 methanandamide activated the CB1 receptor with a Ki value of 26 nM. S-2 methanandamide was less prone to FAAH inactivation. S-2 methanandamide inhibited the murine vas deferens twitch response with an IC50 value of 47 nM.
References:
[1] Abadji V, Lin S, Taha G, et al. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Howlett A C. Cannabinoid receptor signaling[M]//Cannabinoids. Springer Berlin Heidelberg, 2005: 53-79.
m.cnreagent.com