| CAS NO: | 1229652-22-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 463.3 |
| Cas No. | 1229652-22-5 |
| Formula | C24H19BFNO5S |
| Synonyms | Autotaxin Inhibitor IV |
| Solubility | ≤30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| Chemical Name | B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid |
| Canonical SMILES | FC1=CC=C(CN2C(/C(SC2=O)=C/C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50 = 5.7 nM
HA155 is an autotaxin inhibitor.
Autotaxin (ATX), a secreted phosphodiesterase, hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been reported to be involved in fibrosis, inflammation, and tumor progression, rendering ATX an attractive drug target.
In vitro: HA155 was identified as a boronic acid-based inhibitor of ATX based on the crystal structure of ATX in complex with HA155. Furthermore, the syntheses and activities of HA155 could be explained by structural data. In order to further understand the difference in activity, molecular docking experiments were performed. The molecular docking indicated a remarkable binding pose for one of the isomers, which differed from the original binding pose of HA155 for ATX. Moreover, the thrombin-mediated increase in platelet-derived LPA was completely attenuated in a dose-dependent manner by HA155. HA-155 could inhibit autotaxin by selectively binding to its catalytic threonine. HA155 showed to dose-dependently block thrombin-induced LPA secretion in platelets [1,2].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Albers, H. M.H.G.,Hendrickx, L.J.D.,van Tol, R.J.P., et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry 54(13), 4619-4626 (2011).
[2] Fulkerson, Z. ,Wu, T.,Sunkara, M., et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. The Journal of Biological Chemisty 286(40), 34654-34663 (2011).
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