| CAS NO: | 330796-58-2 |
| 包装 | 价格(元) |
| 1mg (solution) | 电议 |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| Physical Appearance | A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 350.5 |
| Cas No. | 330796-58-2 |
| Formula | C21H34O4 |
| Synonyms | 5,6-trans U-46619 |
| Solubility | ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide;2mg/ml in PBS(pH7.2) |
| Chemical Name | 9,11-dideoxy-9α,11α-methanoepoxy-prosta-5E,13E-dien-1-oic acid |
| Canonical SMILES | CCCCC[C@H](O)/C=C/[C@H]1C2OCC(C2)[C@@H]1C/C=C/CCCC(O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].
The biological activity of 5-trans U-46619 has been rarely tested separately from U-46619 itself. In the only case published to date, 5-trans U-46619 was found to be a about half as potent an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619 [1]. Thromboxane A2 (TxA2) has been involved in the pathogenesis of airway hyperresponsiveness. TXA2 is a type of thromboxane produced by activated platelets and shows prothrombotic properties. Thromboxane A2 has also been known as a vasoconstrictor and is especially important during tissue injury and inflammation [3].
References:
[1] Quraishi O, Mancini J A, Riendeau D. Inhibition of inducible prostaglandin E 2 synthase by 15-deoxy-Δ 12, 14-prostaglandin J 2 and polyunsaturated fatty acids[J]. Biochemical pharmacology, 2002, 63(6): 1183-1189.
[2] Coleman, R. A.,Humphrey, P.P.A.,Kennedy, I., et al. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. British Journal of Pharmacology 73, 773-778 (1981).
[3] Svensson J, Strandberg K, Tuvemo T, et al. Thromboxane A2: Effects of airway and vascular smooth muscle[J]. Prostaglandins, 1977, 14(3): 425-436.
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