| CAS NO: | 185351-19-3 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 360.4 |
| Cas No. | 185351-19-3 |
| Formula | C21H16N2O4 |
| Synonyms | 1,4-Naphthoquinon-2-yl-L-tryptophan |
| Solubility | ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan |
| Canonical SMILES | O=C(C=C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)C3=O)C4=C3C=CC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
NQTrp, also known as 1,4-naphthoquinon-2-yl-L-tryptophan, is an inhibitor of the Alzheimer’s disease-associated β-amyloid [1].
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the early soluble oligomeric species of Aβ plays a fundamental role in the pathogenesis of AD [1]. The Aβ peptide results from the cleavage of the amyloid precursor protein (APP) by the β- and γ-secretases and the predominant Aβ peptides found in the brain are 40 (Aβ1-40) and 42 (Aβ1-42) residues [2].
In the oligomer inhibition assay and ThT fibril inhibition assay, NQTrp completely inhibited Aβ oligomerization and fibrillization. In cultured neural cells, NQTrp dose-dependently inhibited Aβ to assemble into toxic oligomers. In rat PC12 neuronal cell line, NQTrp significantly inhibited the cytotoxic effect of the Aβ oligomers and increased the viability of the cells [1].
In a Drosophila model of AD, NQTrp prolonged the life span of Aβ1–42-expressing flies. Aβ1–42-expressing flies with NQTrp displayed dramatic improvement, behaving almost identical to the control classes. The brains of these flies showed a significant reduction in oligomeric species of Aβ [1].
References:
[1]. Scherzer-Attali R, Pellarin R, Convertino M, et al. Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS One. 2010 Jun 14;5(6):e11101.
[2]. Zhang T, Xu W, Mu Y, et al. Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem Neurosci. 2014 Feb 19;5(2):148-59.
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