| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 16189 | Accession #: | P07750 |
| Alternate Names: | IL4, BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra. | ||
| Source: | Escherichia Coli. | M.Wt: | 13.5 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Lyophilized with no additives. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
IL-4 is a pleiotropic cytokine produced by activated T lymphocytes, basophils, mast cells and bone marrow stromal cells. IL-4 plays an important role in the regulation of isotype switching, differentiation of precursor T helper cells and induction of IgE production in B lymphocytes. Also, IL-4 regulates cell proliferation, survival and gene expression. Excessive IL-4 production by Th2 cells is associated with elevated IgE production and allergy.
The murine IL-4 cDNA encodes a 140 aa protein with a 20 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
| Determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells. | ||||||
| ED50 | < 2.0 ng/ml. | |||||
| Specific activity | > 5*105units/mg. | |||||
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