| CAS NO: | 39025-23-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | Off-white solid |
| Storage | Store at RT |
| M.Wt | 312.45 |
| Cas No. | 39025-23-5 |
| Formula | C21H28O2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥3.12 mg/mL in DMSO with gentle warming and ultrasonic |
| Chemical Name | (8S,9R,10R,13R,14S,Z)-17-ethylidene-10,13-dimethyl-7,8,9,10,11,12,13,14,15,17-decahydro-1H-cyclopenta[a]phenanthrene-3,16(2H,6H)-dione |
| Canonical SMILES | O=C1C[C@H]([C@@](/C1=C/C)(C)CC2)[C@@H](CC3)[C@@H]2[C@](CC4)(C)C3=CC4=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Z-Guggulsterone, a constituent of Indian Ayurvedic medicinal plantCommiphora mukul, a broad-spectrum ligand of steroid hormone receptors, with IC50 values of 1740, 1000, 220 and > 50000 nM for glucocorticoid, mineralocorticoid, androgen and farnesoid X receptors, respectively, as well as EC50 values of 1200 and > 5000 nM for progesterone and estrogen receptors, correspondingly [1].
Steroid hormone receptors, found in the nucleus, cytosol, and also on the plasma membrane of target cells, transcribe genes that lead to important biological processes, including normal organ development and function, tissue differentiation, and promotion of oncogenic transformation [2].
In human umbilical vein endothelial cells (HUVEC) and DU145 cells, z-guggulsterone (5, 10 and 20 μM) significantly decrease cell migration in a concentration- and time-dependent manner, inhibiting capillary-like tube formation [3].
Oral gavage of z-guggulsterone (1 mg per day, five times per week) to male nude mice inhibitedin vivo angiogenesis in DU145-Matrigel plug assay as evidenced by a statistically significant decrease in tumor burden, microvessel area, and vascular endothelial growth factor receptor 2 (VEGF-R2) protein expression [3].
References:
[1]. Burris T P, Montrose C, Houck K A, et al. The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. Molecular Pharmacology, 2005, 67(3): 948-954.
[2]. Levin E R. Rapid signaling by steroid receptors. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008, 295(5): R1425-R1430.
[3]. Xiao D, Singh S V. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Molecular Cancer Therapeutics, 2008, 7(1): 171-180.
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