| CAS NO: | 2642-37-7 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 251.3 |
| Cas No. | 2642-37-7 |
| Formula | C8H6KNO4S |
| Solubility | insoluble in EtOH; ≥25.15 mg/mL in H2O; ≥51.9 mg/mL in DMSO |
| Chemical Name | potassium 1H-indol-3-yl sulfate |
| Canonical SMILES | [O-]S(OC1=CNC2=CC=CC=C21)(=O)=O.[K+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease[1]. Indoxyl sulfate at 250 μM can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity[2].
References：
[1]. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J.Med.Sci, 2010, 72(1-2): 1-11.
[2]. Shimizu H, Yisireyili M, Nishijima F, et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol, 2013, 37(2): 97-103.
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