| CAS NO: | 16326-32-2 |
| 包装 | 价格(元) |
| 50mg (solution) | 电议 |
| 100mg (solution) | 电议 |
| 250mg (solution) | 电议 |
| 1g (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 292.5 |
| Cas No. | 16326-32-2 |
| Formula | C19H32O2 |
| Synonyms | Methyl GLA,Methyl γ-Linolenate |
| Solubility | ≤100mg/ml in DMSO;100mg/ml in dimethyl formamide |
| Chemical Name | 6Z,9Z,12Z-octadecatrienoic acid, methyl ester |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease.
In vitro: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM [1].
In vivo: In an in-vivo model of LTB4-induced bronchoconstriction, ricinelaidic acid andγ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Yagaloff, K. A.,Franco, L.,Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukotrienes and Essential Fatty Acids 52, 293-297 (1995).
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