Rimantadine Hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1501-84-4

包装与价格：

包装	价格(元)
100mg	电议
1g	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	215.76
Cas No.	1501-84-4
Formula	C₁₂H₂₂ClN
Solubility	≥21.6 mg/mL in DMSO; ≥9.24 mg/mL in H2O; ≥9.88 mg/mL in EtOH
Chemical Name	(R)-1-((1s,3R,5S,7S)-adamantan-1-yl)ethanamine hydrochloride
Canonical SMILES	CC(C12CC3CC(C1)CC(C3)C2)N
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

In a variety of tissue culture systems, rimantadine (25 μg/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL). Rimantadine significantly inhibited dengue virus replication in cultures of rhesus monkey PBL. In virus-infected LLC-MK2 cell cultures, rimantadine decreased the production of all four types of dengue virus [1]. Rimantadine interfered with the generation of cellular immune responses. Rimantadine hydrochloride inhibited the proliferative response of human peripheral blood lymphocytes to mitogenic and antigenic stimulation. Rimantadine hydrochloride (25 μg/ml) suppressed the responses to phytohemagglutinin, pokeweed mitogen, and concanavalin A by 25, 65, and 90%, respectively. rimantadine (10 μg/ml) significantly inhibited responses to streptokinase-streptodornase, tetanus toxoid, and A2/Aichi influenza vaccine [2]. In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine (200 mg/day for 5 days) significantly reduced nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms [3].

References:
[1] Koff W C, Elm Jr J L, Halstead S B. Suppression of dengue virus replication in vitro by rimantadine hydrochloride[J]. The American journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] Koff W C, Peavy D L, Knight V. Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[J]. Infection and immunity, 1979, 23(3): 665-669.
[3] Hayden F G, Monto A S. Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults[J]. Antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.