IGF-1,human recombinant

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	100ug
市场价:	3500元

产品介绍

描述

Gene ID:	3479	Accession #:	P05019
Alternate Names:	IGF1A, Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.
Source:	Escherichia Coli.	M.Wt:	7.6 kDa
Appearance:	Lyophilized powder	Storage:	Store at -20°C
Formulation:	Lyophilized with no additives.
Solubility:	Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition:	Gel pack.	Handling:	Centrifuge the vial prior to opening.
Usage:	For Research Use Only! Not to be used in humans.

资料参考

Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue. IGF-1 binds and interacts with the IGF-1 binding proteins (IGFBPs). IGF-1 binds to the IGF-1 receptor with a higher affinity than the insulin receptor.

Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.6 kDa mature IGF-I. Mature human IGF I shares 94% and 96% aa sequence identity with mouse IGF1 and rat IGF1, respectively, and exhibits cross species activity. Human IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. The recombinant human IGF-1 was produced using animal origin free technology.

生物活性

Determined using dose dependent stimulation of Balbc 3T3 cell line.
ED₅₀	21.6-54.7 ng/ml.