| CAS NO: | 1643125-32-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1643125-32-9 |
| Canonical SMILES | O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(O)=O)=CC=C2)CCC3=CC(OC)=C(OC)C=C3)=O)[C@@H](C4CCCCC4)C5=CC(OC)=C(OC)C(OC)=C5 |
| 分子式 | C42H53NO11 |
| 分子量 | 747.87 |
| 溶解度 | Methanol : 125 mg/mL (167.14 mM);DMSO : 62.5 mg/mL (83.57 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2]. SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range[1]. [1]. Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7. [2]. Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62(1):116-128. |
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