GK187 是一种有效且选择性的 VIA 组钙非依赖性磷脂酶 A2 (GVIA iPLA2) 抑制剂，XI(50) 值为 0.0001。
| Cas No. | 1071001-50-7 |
| Canonical SMILES | COC1=CC=C(CCCCC(C(F)(F)C(F)(F)F)=O)C=C1 |
| 分子式 | C14H15F5O2 |
| 分子量 | 310.3 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows less than 25% and 32.8% inhibition, respectively. |
m.cnreagent.com