Paxilline

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Paxilline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

57186-25-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Desiccate at -20°C
M.Wt	435.56
Cas No.	57186-25-1
Formula	C₂₇H₃₃NO₄
Solubility	Soluble in DMSO
Chemical Name	(2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
Canonical SMILES	O[C@]1(C2=C3)[C@@](CC[C@@H]2O[C@H](C(C)(C)O)C3=O)(C)[C@](C(NC4=CC=CC=C54)=C5C6)(C)[C@@H]6CC1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca²⁺-activated K⁺ (BKCa, KCa1.1) channels[1,2]. It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels. Paxilline also inhibits the sarco/endoplasmic reticulum Ca²⁺ ATPase (IC50 = 5 - 50 μM)[3].

References:

[1]. Sanchez M, McManus O B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology, 1996, 35(7): 963-968.

[2]. Li G, Cheung D W. Effects of paxilline on K⁺ channels in rat mesenteric arterial cells. European Journal of Pharmacology , 1999, 372: 103-107.

[3]. Knaus H G, McManus O B, Lee S H, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry, 1994, 33(19): 5819-5828.