| CAS NO: | 5108-96-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 164.28 |
| Cas No. | 5108-96-3 |
| Formula | C5H12N2S2 |
| Synonyms | PDTC |
| Solubility | insoluble in H2O; ≥12.975 mg/mL in EtOH with gentle warming; ≥7.3 mg/mL in DMSO |
| Chemical Name | ammonium pyrrolidine-1-carbodithioate |
| Canonical SMILES | [S-]C(N1CCCC1)=S.[NH4+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Pyrrolidinedithiocarbamate Ammonium is a potent inhibitor of nuclear factor-κB (NF-κB) [1].
NF-κB is a protein complex that controls DNA transcription and cytokine production. It is not only an important factor in regulating inflammation and immune responses and cell survival, but also involved in the cell transformation and tumor formation [1].
In human intestinal epithelial cell line HT-29 induced by interleukin-1β (IL-1β), pretreatment of cells with Pyrrolidinedithiocarbamate Ammonium (3 ~ 1000 μM) dose-dependently attenuated interleukin-8 (IL-8) production. Furthermore, Pyrrolidinedithiocarbamate Ammonium (100 μM) suppressed the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate Ammonium inhibited the activation of NF-κB, by suppressing both NF-κB DNA binding and NF-κB-dependent transcriptional activity [2].
In Sprague-Dawley rats pretreated withbacillus Calmette-Guérin(BCG), injection of Pyrrolidinedithiocarbamate Ammonium (50, 100, and 200 mg/kg) reversed hepatic injury stimulated by BCGin vivo. Moreover, Pyrrolidinedithiocarbamate Ammonium inhibited down-regulation of Cytochrome P450 2E1 (CYP2E1) in a dose dependent manner, with ED50 value of 76 mg/kg [1].
References:
[1]. Qin J D, Cao Z H, Li X F, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharmaceutical Biology, 2014, 52(11): 1460-1466.
[2]. Németh Z H, Deitch E A, Szabó C, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunology Letters, 2003, 85(1): 41-46.
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