| CAS NO: | 60-33-3 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Physical Appearance | liquid |
| Storage | Store at -20°C |
| M.Wt | 280.45 |
| Cas No. | 60-33-3 |
| Formula | C18H32O2 |
| Solubility | insoluble in H2O; ≥29 mg/mL in EtOH; ≥31.6 mg/mL in DMSO |
| Chemical Name | (9Z,12Z)-octadeca-9,12-dienoic acid |
| Canonical SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Linoleic acid is a critical component of polyunsaturated fatty acids, of which the catabolism exacerbates the oxidation reaction and causes damage to red blood cell membranes causing hidden blood loss (HBL) after THA and TKA[1].
Glutathione peroxidase (GSH-PX) is an enzyme that scavenges free radicals and catalytically breaks down hydrogen peroxide, protecting cell membrane structure and function from damage. Superoxide dismutase (SOD) is a ubiquitous antioxidant enzyme found in aerobic organisms that helps remove superoxide free radicals and protects against the toxic effect of oxygen free radicals.
The linoleic acid-treatment rats were treated with four different concentrations of linoleic acid diluted in 20% ethanol by intravenous administration into the tail vein. HBL occurred when linoleic acid was administered at a concentration of 60 mmol/L. Red blood cell count and hemoglobin levels were significantly reduced by 24 h post-injection, following by erythrocyte deformation, reduced activity of GSH-PX and T-SOD, and decreased levels of H2O2. This was accompanied by an increase in ferryl species, which likely contributes to oxidative stress invivo [1].
Reference:
[1] Yuan T, Fan W B, Cong Y, et al. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. Int J Clin Exp Pathol. 2015, 8(5): 5044-5052.
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