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Veratridine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Veratridine图片
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Veratridine (3-Veratroylveracevine) 是一种植物神经毒素,一种电压门控钠通道 (VGSCs) 阻滞剂。

Cell lines

HCT-116 colon cancer cells (expressing GFP-UBXN2A)

Preparation method

The solubility of this compound in DMSO is >10mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

20 and 40 μM, 24 hours

Applications

Veratridine is the main UBXN2A enhancer, increased UBXN2A protein levels in a dose-dependent manner.

Animal models

C57Bl/6N mice( HCT-116 cells expressing GFP-UBXN2A were injected into 6 to 8 week old nude female mice)

Dosage form

Intraperitoneal injection (IP), 0.125 mg/kg for 28 days

Application

Veratridine (VTD) was sufficient to induce UBXN2A protein levels, resulting in colon cancer cell death in UBXN2A- and mot-2-dependent manners.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

产品描述

Voltage-gated Na+channel opener; increases intracellular Ca2+with no effect on the Na+/Ca2+exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+permeability and depolarizes excitable tissues.

Reference:
[1]. Purification, solubility and pKa of veratridine.
McKinney et al.
Anal.Biochem., 1986;153:33
[2]. Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.
Maroto et al.
Eur.J.Pharmacol., 1994;270:331
[3]. Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy.
Fekete et al.
J.Neurochem., 2009;111:745