WP1066 is an inhibitor ofJAK2andSTAT3, and also shows effect onSTAT5and ERK1/2, without affectingJAK1andJAK3.

WP1066 markedly inhibits the growth of HEL cells in a dose-dependent manner. The IC₅₀value for inhibition of the proliferation of HEL cells is 2.3 μM. WP1066 inhibits the growth of human HEL cells carrying the JAK2 V617F mutant isoform^[1]. Blockade of p-STAT3 with WP1066 enhances the cytotoxic effects of CTX on the tumor. The IC₅₀doses of WP1066 for B16 cells is 2.43 μM (0.865 μg/mL)^[2]. WP1066 inhibits AML blast colony-forming cell proliferation, suppresses normal BM progenitor proliferation at increased concentrations, and inhibits AML colony-forming cell proliferation^[3].

WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment^[2].

356.22

Solid

C₁₇H₁₄BrN₃O

857064-38-1

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 44 mg/mL(123.52 mM)

Ethanol : 16.67 mg/mL(46.80 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。