Gypenoside LI 是一种绞股蓝赶单体，具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。
| 生物活性 | Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cellapoptosis, cell cycle and migration[1][2]. |
体外研究
(In Vitro) | Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1].
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1].
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than
CDK2 and CDK4 proteins[1].
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2].
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2].
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2].
Cell Viability Assay[1] | Cell Line: | A549 cells. | | Concentration: | 0-80 μM. | | Incubation Time: | 24 h. | | Result: | Displayed the strongest activity with the IC50values of 21.36 ± 0.78 μM. |
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| 来源 | - Plants
- Cucurbitaceae
- Gynostemma pentaphyllum(Thunb.) Makino
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| 溶解性数据 | In Vitro: DMSO : 100 mg/mL(124.84 mM;Need ultrasonic) 配制储备液 | 1 mM | 1.2484 mL | 6.2421 mL | 12.4842 mL | | 5 mM | 0.2497 mL | 1.2484 mL | 2.4968 mL | | 10 mM | 0.1248 mL | 0.6242 mL | 1.2484 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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