Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulatesadenylate cyclaseactivity in particulate fractions of both heart and gill tissues withEC₅₀s of 0.1 and 1.0 μM, respectively.

EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)^[1]

Small cardioactive peptide B (SCP_B) is a neurally active peptide endogenous toAplysia. Small cardioactive peptide B (SCP_B) possesses cardioexcitatory effects inAplysiaand reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP_B) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP_B) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP_B) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP_B) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC₅₀values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP_B) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC₅₀value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP_B)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP_B) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC₅₀of 0.1 and 1.0μM, respectively^[1].

1141.41

Solid

C₅₂H₈₀N₁₄O₁₁S₂

84746-43-0

Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2

MNYLAFPRM-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

H₂O : 50 mg/mL(43.81 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。