AB-680 ammonium is a highly potent, reversible and selective inhibitor ofCD73(an ecto-nucleotidase), with aK_iof 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidasesCD39. Anti-tumor activity^[1].

Ki: 4.9 pM (hCD73)^[1]

AB-680 ammonium inhibits soluble hCD73 with an IC₅₀of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8⁺T Cells and hPBMC, with IC₅₀s of 0.070, 0.008, 0.66 and 0.011 nM, respectively^[1].

614.89

C₂₀H₃₀ClFN₆O₉P₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.