Ro 24-5913 (Cinalukast) is an orally active and potentLTD4antagonist with anIC₅₀value of 6.4 nM. Ro 24-5913 can be used for the research of asthma^[1].

IC50: 6.4 nM (LTD4)^[1]

Ro 24-5913 competes with [³H]LTD4 for its binding site in guinea pig lung membranes with an IC₅₀value of 6.4 nM^[1].
Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pK_Bvalue of 9.3^[1].

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD₅₀s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively^[1].

412.55

C₂₃H₂₈N₂O₃S

128312-51-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.