CAS NO: | 142846-71-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GalaninReceptor Ligand M35 is a high-affinity ligand and antagonist ofgalaninreceptor(Kd=0.1 nM).GalaninReceptor Ligand M35 exerts aKivalues of 0.11 and 2.0 nM for humangalaninreceptor type 1 and 2, respectively[1][2]. | ||||||||||||||||
IC50& Target | Kd: 0.1 nM (galanin receptor)[1] | ||||||||||||||||
体外研究 (In Vitro) | Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP[1]. | ||||||||||||||||
体内研究 (In Vivo) | Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[1]. | ||||||||||||||||
分子量 | 2233.60 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C107H153N27O26 | ||||||||||||||||
CAS 号 | 142846-71-7 | ||||||||||||||||
Sequence | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 | ||||||||||||||||
Sequence Shortening | GWTLNSAGYLLGPPPGFSPFR-NH2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(44.77 mM;Need ultrasonic) H2O : 50 mg/mL(22.39 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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