GPX4-IN-2

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GPX4-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2485005-22-7

包装与价格：

产品介绍

GPX4-IN-2 是一种有效的GPX4抑制剂。GPX4 显示出抗增殖活性。GPX4-IN-2具有癌症研究的潜力。

生物活性

GPX4-IN-2 is a potentGPX4inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research ofcancer^[1].

IC₅₀& Target

GPX4^[1]

体外研究
(In Vitro)

GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) 显示出抗增殖活性，对于 786-O、SJSA-1、A431 细胞的 IC₅₀值分别为 0.004、0.016、2.9 μM^[1]。

Cell Proliferation Assay^[1]

Cell Line:	SJSA-1, 786-O, A431 cells
Concentration:	0.0005-10 mM
Incubation Time:	24 h
Result:	Inhibited cell proliferation with IC₅₀s of 0.004, 0.016, 2.9 μM for 786-O, SJSA-1, A431 cells, respectively.

体内研究
(In Vivo)

GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) 在小鼠和大鼠中显示出良好的药代动力学特征^[1]。

Animal Model:	6-8 weeks, 22-25 g, Male Balb/c mice, 6-8 weeks, 200-250 g, male SD rats^[1]
Dosage:	5 mg/kg for mouse, 2 mg/kg for rats
Administration:	I.v.
Result:	Showed a good pharmacokinetics with T_1/2of 3.5 h, C_maxof 5446 ng/mL, AUC of 1635 ng·h/mL, CL of 49 mL/min/kg, Vd of 14.7 L/kg in mice, T_1/2of 3.15 h, C_maxof 3529 ng/mL, AUC of 1082 ng·h/mL, CL of 30 mL/min/kg, Vd of 8.2 L/kg in rats.

分子量

444.65

Formula

C₃₀H₄₀N₂O

CAS 号

2485005-22-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.