Phosphoramidon

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Phosphoramidon

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

36357-77-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

磷酰胺

产品介绍

Phosphoramidon，一种微生物代谢物 (microbial metabolite)，是一种特异性金属蛋白酶嗜热菌蛋白酶 (metalloprotease thermolysin) 抑制剂，其IC₅₀为0.4 μg/mL。Phosphoramidon 也抑制内皮素转换酶 (ECE)、中性肽酶 (NEP) 和血管紧张素转换酶 (ACE)，IC₅₀分别为 3.5、0.034 和 78 μM。

生物活性

Phosphoramidon, amicrobial metabolite, is a specificmetalloprotease thermolysininhibitor with anIC₅₀of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), andangiotensin-converting enzyme(ACE) withIC₅₀values of 3.5, 0.034, and 78 μM, respectively^[1]^[2]^[3].

IC₅₀& Target^[1]

Microbial Metabolite

体外研究
(In Vitro)

Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes^[5].

体内研究
(In Vivo)

Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats^[4].
Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats^[5].

Animal Model:	Male Sprague-Dawley rats^[4]
Dosage:	0.25 mg/kg per min
Administration:	Intravenous injection
Result:	Markedly suppressed the hypertensive effect of big endothelin-1.

分子量

543.50

Formula

C₂₃H₃₄N₃O₁₀P

CAS 号

36357-77-4

中文名称

磷酰胺

结构分类

Ketones, Aldehydes, Acids

来源

Streptomyces tanashiensis

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.