Nepodin

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Nepodin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

3785-24-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

Musizin

产品介绍

Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂，从Rumex crispus中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。

生物活性

Nepodin (Musizin) is aquinone oxidoreductase (PfNDH2)inhibitor isolate fromRumex crispus^[1].Nepodin (Musizin) stimulates the translocation ofGLUT4to the plasma membrane by activation ofAMPK^[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

IC₅₀& Target

Plasmodium

体外研究
(In Vitro)

Nepodin (Musizin) exhibits significant IC₅₀values that are 0.74 and 0.79 μg/ml againstP. falciparumchloroquine-sensitive (3D7) andP. falciparumchloroquine-resistant (S20), respectively^[1].

体内研究
(In Vivo)

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner^[2].

Animal Model:	C57BL/KsJ-db/db mice^[2]
Dosage:	2 mg/kg; 10 mg/kg
Administration:	Orally administration; 2-10 mg/kg; 4 weeks
Result:	Had antihyperglycemic potential and improved insulin resistance.

分子量

216.23

性状

Solid

Formula

C₁₃H₁₂O₃

CAS 号

3785-24-8

结构分类

Phenols
Polyphenols

来源

Plants
Polygonaceae
Rumex japonicusHoutt.

Plants
Polygonaceae
Rumex crispusLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 125 mg/mL(578.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.6247 mL	23.1235 mL	46.2471 mL
5 mM	0.9249 mL	4.6247 mL	9.2494 mL
10 mM	0.4625 mL	2.3124 mL	4.6247 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。