VER-50589 is aHsp90inhibitor, with anIC₅₀of 21 nM and aK_dof 4.5 nM.

VER-50589 is a Hsp90 inhibitor, with an IC₅₀of 21 nM and a K_dof 4.5 nM. VER-50589 inhibits intrinsic ATPase of full-length recombinant yeast Hsp90, with an IC₅₀of 143 ± 23 nM in the presence of 400 μM ATP. VER-50589 shows antiproliferative activities against various human cancer cells, with the lowest GI₅₀of 32.7 ± 0.2 nM for CH1 human ovarian cells, and mean GI₅₀of 78 ± 15 nM. VER-50589 suppressses the proliferation of human umbilical vein endothelial cells (HUVEC) with GI₅₀value of 19 ± 2.4 nM, and shows higher GI₅₀s against nontumorigenic human breast (MCF10a) and prostate (PNT2) epithelial cells. Furthermore, VER-50589 displays no differences in cellular activities of isogenic cell lines, and these activities are independent of NQO1 expression. VER-50589 also causes G1 and G2-M block (115 or 575 nM) and induces cytostasis in HCT116 colon cancer cells. In addition, VER-50589 causes great uptake in HCT116 cells^[1].

VER-50589 (4 mg/kg, i.p.) exerts a complete HSP90 inhibition in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors. VER-50589 (100 mg/kg, i.p.) shows reduced tumor volume and tumor weights in the HCT116 colon carcinoma xenografts compared to the control mice group^[1].

388.80

Solid

C₁₉H₁₇ClN₂O₅

747413-08-7

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 48 mg/mL(123.46 mM)

*"≥" means soluble, but saturation unknown.

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