Rotundine is an antagonist ofdopamine D1,D2andD3 receptorswithIC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of5-HT_1Awith anIC₅₀of 370 nM.

It is reported that Rotundine (l-THP) possesses a blocking effect on dopamine D₁and D2receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group [F(3, 37)=1.360, P>0.05, F(3, 37)=0.348, P>0.05, respectively]. Locomotor counts are greatly increased in the oxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone [F(4, 60)=15.76, P<0.01]. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization [F(4, 62)=8.766, P<0.01]^[2].

355.43

Solid

C₂₁H₂₅NO₄

483-14-7

罗通定；罗痛定；颅通定；颅痛定；(-)-四氢帕马丁；(-)-延胡索乙素；L-四氢帕马丁；L-延胡索乙素

• Alkaloids
• Isoquinoline Alkaloids

• Plants
• Papaveraceae
• Corydalis yanhusuoW. T. Wang

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 100 mg/mL(281.35 mM)

H₂O : 0.67 mg/mL(1.89 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

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