Rodatristat

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Rodatristat

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1673568-73-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品名称

KAR5417

产品介绍

Rodatristat (KAR5417) 是一种有效的tryptophan hydroxylase 1 (TPH1)和TPH2抑制剂，其IC₅₀值分别为 33 nM 和 7 nM，并显著降低小鼠肠道中的血清素 (5-HT) 水平。

生物活性

Rodatristat (KAR5417) is a potenttryptophan hydroxylase1 (TPH1)andTPH2inhibitor withIC₅₀s value of 33 nM and 7 nM, respectively, and shows robust reduction ofintestinal serotonin (5-HT)levels in mice^[1].

IC₅₀& Target^[1]

serotonin

TPH1

33 nM (IC₅₀)

TPH2

7 nM (IC₅₀)

体内研究
(In Vivo)

Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose^[1].

Animal Model:	Mice^[1]
Dosage:	10 mg/kg and 50 mg/kg
Administration:	Oral administration
Result:	Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose.

Clinical Trial

分子量

561.98

Formula

C₂₇H₂₇ClF₃N₅O₃

CAS 号

1673568-73-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.