WAY-181187 (SAX-187) oxalate is a potent and selective full5-HT6receptor agonist with aK_iof 2.2 nM and anEC₅₀of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist^[1][2].

WAY-181187 (SAX-187) oxalate (1 and 10 μM) increases activation of ERK1/2. WAY181187 also increases Fyn kinase activity^[2].

Acute administration of WAY-181187 (SAX-187) oxalate (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 oxalate (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels^[1].

470.91

C₁₇H₁₅ClN₄O₆S₂

1883548-85-3

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Please store the product under the recommended conditions in the Certificate of Analysis.