BRL-15572 hydrochloride is a selective antagonist ofh5-HT1D, displays high affinity forh5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise5-HT1D receptormediated responses^[1].

BRL-15572 has 60-fold higher affinity for h5-HT1D (pK_i=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells^[1].
BRL-15572 (0.1 nM-10 μM) stimulates [³⁵S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors^[1].

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test^[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig^[3].

443.41

C₂₅H₂₈Cl₂N₂O

1173022-77-9

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