Ro 04-6790 is a potent, competitive and selective5-HT₆receptor antagonist withpK_ivalues of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors^[1].

Ro 04-6790 has over 100 fold selective for the 5-HT₆receptor compared to other receptor binding sites (IC₅₀>10 μM)^[1].

Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)^[2].

308.36

C₁₂H₁₆N₆O₂S

202466-68-0

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Please store the product under the recommended conditions in the Certificate of Analysis.