EMD386088

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EMD386088

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1171123-46-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

EMD386088 是一种有效的5-羟色胺 6 受体 (5-HT6R) 激动剂。EMD386088 诱导细胞死亡。EMD386088 调节 ERK1/2 的活性。EMD386088具有研究阿尔茨海默病（AD）和精神分裂症的潜力。

生物活性

EMD386088 is a potentserotonin 6 receptor (5-HT6R)agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia^[1]^[2]^[3].

IC₅₀& Target^[1]

5-HT₆Receptor

体外研究
(In Vitro)

EMD386088 (1, 10, 60 μM; 0-18 h) induces cell death in a dose- and time- dependent manner^[1].
EMD386088 (1, 10, 60 μM) regulates the activity of ERK1/2 in a 5-HT6R-dependent and 5-HT6R–independent manner^[1].

Cell Viability Assay^[1]

Cell Line:	HEK/HA-5-HT6R, native HEK293 cells
Concentration:	1, 10, 60 μM
Incubation Time:	0-18 h
Result:	Induced cell death in HEK293 cells stably expressing HA-5-HT6R (HEK/HA-5-HT6R) and in native HEK293 cells in a dose- and time- dependent manner.

Western Blot Analysis^[1]

Cell Line:	HEK/HA-5-HT6R, native HEK293 cells
Concentration:	1, 10, 60 μM
Incubation Time:	0-18 h
Result:	Led to the activation of ERK1/2 at 0-30 μM, retarded ERK1/2 activation at a high dose of 60 μM in HEK/HA-5-HT6R cells.

体内研究
(In Vivo)

EMD386088 (1, 5, 10 mg/kg) impairs both short-term memory (STM) and long-term memory (LTM) at 5 mg/kg, but produces no significant effects at 10 mg/kg in male Wistar rats^[2].
EMD386088 (0, 2, 4 mg/kg) significantly impairs spontaneous alternation performancein at 2 mg/kg, but the high dose of 4 mg/kg dose not reach significance in C57BL/6J mice^[3].

分子量

283.20

Formula

C₁₄H₁₆Cl₂N₂

CAS 号

1171123-46-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.