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过氧化物酶体生成蛋白5相关蛋白抗体
过氧化物酶体生成蛋白5相关蛋白抗体图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Anti-PEX5L
Anti-peroxisomal biogenesis factor 5 like Antibody
产品介绍
靶标:

PEX5L


产品别名:

PEX5R; PEX5RP; PXR2; PXR2B; TRIP8b; PEX5L; peroxisomal biogenesis factor 5 like; peroxisomal biogenesis factor 5 like; PEX5-related protein; HCN channel auxiliary subunit; PEX2-related protein; PEX5-like protein; Pex5p-related protein; peroxin-5-related protein; peroxisome biogenesis factor 5-like; tetratricopeptide repeat-containing Rab8b-interacting protein; 过氧化物酶体生成蛋白5相关蛋白;


背景信息:
PEX5R (also called TRIP8b, tetratricopetide repeat-containing Rab8b-interacting protein) is a cytoplasmic protein expressed as a family of alternatively spliced isoforms. PEX5R /TRIP8b isoforms contain a large constant domain preceded by a variable region. The C-terminal half of TRIP8b comprises a tetratricopeptide repeat (TPR) protein binding domain. Analysis of the Pex5p-like protein revealed the presence of a tetratricopeptide repeat (TPR) domain in its C-terminal half consisting of seven TPR motifs. Pex5R is almost exclusively expressed in brain. Recent studies provide strong evidence that PEX5R interacts with the carboxyl-terminal region of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and regulates their cell-surface expression level and cyclic nucleotide dependence. HCN channels are key modulators of neuronal activity by providing the depolarizing cation current involved in rhythmogenesis, dendritic integration, and synaptic transmission. In contrast, Gosh et al. have shown that human PEX5R can bind to peroxisomal targeting signal-1 (PTS1) ligands. Furthermore it was shown that enzyme alanine–glyoxylate aminotransferase (AGT) is recognized by PEX5R in the cytoplasm, which allows its subsequent translocation into the peroxisome. TRIP8b may play a role in both normal neuronal function and in aberrant neuronal excitability associated with neurological diseases.

宿主:Rbt
类型:Pab
同种型:IgG  
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user           
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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